PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism.
Ni C, Liu W, Zheng K, Guo S, Song B, Jing W, Li G, Li B, Ni C, Shi K, Jin G, Yu G.
Ni C, et al.
Int J Biol Sci. 2023 Mar 27;19(6):1968-1982. doi: 10.7150/ijbs.77150. eCollection 2023.
Int J Biol Sci. 2023.
PMID: 37063434
Free PMC article.
Simultaneous expression of HPRT1 and IMPDH2 would mainly rescue the phenotypes of cells lacking AFF4. Additionally, xenograft study proved HPRT1 and IMPDH2 genetically function in the downstream of AFF4, which was recruited by PAX2 when CDK9 mediated AFF4 phosphoryl …
Simultaneous expression of HPRT1 and IMPDH2 would mainly rescue the phenotypes of cells lacking AFF4. Additionally, xenograft study p …